We are facing manifold challenges in the world today, including a global pandemic, war in Europe, the supply chain crisis, and climate change. It is becoming increasingly clear that we can only master these challenges by working together. In the spirit of the 51st St. Gallen Symposium’s theme, generating a “Collaborative Advantage” in the economy, the natural environment, and society is key. Universities play a crucial role in providing answers to these challenges and enabling individuals to collaborate.