The traditional picture of cancer patients as weak individuals requiring maximum rest and protection is beginning to dissolve. Too much focus on the medical side and one’s own vulnerability and mortality might be counterproductive and not doing justice to the complexity of human nature. Unlike cytotoxic and lympho-depleting treatments, immune-engaging therapies strengthen the immune system and are typically less harmful for patients. Thus, cancer patients receiving checkpoint inhibitors are not viewed as being vulnerable per se, at least not in immunological and physical terms. This perspective article advocates a holistic approach to cancer immunotherapy, with an empowered patient in the center, focusing on personal resources and receiving domain-specific support from healthcare professionals. It summarizes recent evidence on non-pharmaceutical interventions to enhance the efficacy of immune checkpoint blockade and improve quality of life. These interventions target behavioral factors such as diet, physical activity, stress management, circadian timing of checkpoint inhibitor infusion, and waiving unnecessary co-medication curtailing immunotherapy efficacy. Non-pharmaceutical interventions are universally accessible, broadly applicable, instantly actionable, scalable, and economically sustainable, creating value for all stakeholders involved. Most importantly, this holistic framework re-emphasizes the patient as a whole and harnesses the full potential of anticancer immunity and checkpoint blockade, potentially leading to survival benefits. Digital therapeutics are proposed to accompany the patients on their mission toward change in lifestyle-related behaviors for creating optimal conditions for treatment efficacy and personal growth.

Was ist die Superpower von Klein- und Mittelunternehmen (KMU) und wie kann sie Unternehmerinnen und Unternehmern in Zeiten von Umbruch und Krisen helfen? Der zehnte und letzte Band in der «Fit für ...»-Reihe der Organisatoren des Schweizer KMU-Tags bringt Inputs zu diesem Thema und stellt Fragen für eine Art «Selbstbesinnung» von KMU-Führungskräften.

Business process thinking and quality management found their way into public services, with a focus on customers, efficiency and performance improvement, from the 1980s onwards. In this chapter, we will show that both process and quality management offer many advantages, particularly in eliminating wasteful activities in public service organizations, helping to redesign processes so that they are more directly oriented to adding value to the organization's external customers, and improving the performance and impact of public administration.

The fast-paced acceleration of digitalization requires extensive re-&upskilling, impacting a significant proportion of jobs worldwide. Technology-mediated learning platforms have become instrumental in addressing these efforts, as they can analyze platform data to provide personalized learning journeys. Such personalization is expected to increase employees’ empowerment, job satisfaction, and learning outcomes. However, the challenge lies in efficiently deploying these opportunities using novel technologies, prompting questions about the design and analysis of generating personalized learning paths in organizational learning. We, therefore, analyze and classify recent research on personalized learning paths into four major concepts (learning context, data, interface, and adaptation) with ten dimensions and 34 characteristics. Six expert interviews validate the taxonomy’s use and outline three exemplary use cases, undermining its feasibility. Information Systems researchers can use our taxonomy to develop theoretical models to study the effectiveness of personalized learning paths in intra-organizational re-&upskilling.