In his posthumously published work, Quine abandons his empiricist principle that humans do not have any innate concepts, or knowledge. He does so in light of empirical research that Penelope Maddy capitalizes on to develop her own naturalized epistemology. The empirical research in question is due to the pioneering work of developmental psychologist Elisabeth Spelke. Spelke employs the method of habituation and preferential looking to argue that human infants have innate concepts, and that they have some knowledge about what can and cannot happen to physical objects. Taking into account empirical studies as well as methodological considerations, this article examines whether this research can support these strong philosophical conclusions drawn from it, finding that it likely cannot provide such support.