The EBMT Activity Survey 2009: Trends over the Past 5 Years
Journal
Bone Marrow Transplantation
ISSN
0268-3369
ISSN-Digital
1476-5365
Type
journal article
Date Issued
2011-02-28
Author(s)
Baldomero, Helen
;
Gratwohl, Alois
;
Gratwοhl, Μichael
;
Tichelli, André
;
Niederwieser, Dietger
;
Madrigal, Alejandro
;
Abstract
Six hundred and twenty-four centers from 43 countries reported a total of 31?322 hematopoietic SCT (HSCT) to this 2009 European Group for Blood and Marrow Transplantation (EBMT) survey with 28?033 first transplants (41% allogeneic, 59% autologous). The main indications were leukemias (31%; 92% allogeneic), lymphomas (58%; 12% allogeneic), solid tumors (5%; 6% allogeneic) and non-malignant disorders (6%; 88% allogeneic). There were more unrelated than HLA-identical sibling donors (51 vs 43%) for allogeneic HSCT; the proportion of peripheral blood as stem cell source was 99% for autologous and 71% for allogeneic HSCT. Allogeneic and autologous HSCT continued to increase by about 1000 HSCT per year since 2004. Patterns of increase were distinct and different. In a trend analysis, allogeneic HSCT increased in all World Bank Categories (P=0.01, two sided; all categories), autologous HSCT increased in middle- (P=0.01, two sided) and low-income (P=0.01, two sided) countries. EBMT practice guidelines appeared to have an impact on trend, with a clear increase in absolute numbers within the categories ‘standard' and ‘clinical option' for both allogeneic and autologous HSCT (P=0.01, two sided; for both allogeneic and autologous HSCT) and a clear decrease in autologous HSCT for the ‘developmental' and ‘generally not recommended' indications (P=0.01, two sided). These data illustrate the status and trends of HST in Europe.
Language
English
Keywords
Hematopoietic SCT
stem cell source
Europe
transplant rates
indication
practice guidelines
HSG Classification
contribution to scientific community
Refereed
Yes
Publisher
Nature Publishing Group
Publisher place
London
Volume
46
Number
4
Start page
485
End page
501
Pages
17
Subject(s)
Division(s)
Eprints ID
222267